The Maine Department of Health and Human Services’ Center for Disease Control and Prevention (Maine CDC) is investigating reports of contaminated IV tubing sets from a single manufacturer with national distribution and alerting Maine health care facilities to inspect their supplies. The contamination is reported as small black dots on the internal walls of the drip chambers and has been reported in numerous lots across three product types from ICU Medical. In some products, particulate matter appears in the lumen or chamber of the tubing. In most, particulate matter appears embedded in the plastic material but not within the lumen or chamber. Preliminary reports of similar findings in one other state suggest this may be a widespread issue with one or more nationally-distributed product lines.